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Pathophysiologically based drug treatment of sickle cell disease.
Steinberg MH. Steinberg MH. Trends Pharmacol Sci. 2006 Apr;27(4):204-10. doi: 10.1016/j.tips.2006.02.007. Epub 2006 Mar 13. Trends Pharmacol Sci. 2006. PMID: 16530854 Review.
This multifaceted pathophysiology provides the opportunity to interrupt the disease at multiple sites, including polymerization of HbS, erythrocyte density and cell-cell interactions. ...Furthermore, it is possible to improve the hydration of sickle erythrocytes and it mig …
This multifaceted pathophysiology provides the opportunity to interrupt the disease at multiple sites, including polymerization of Hb …
A Methyltransferase Inhibitor (Decitabine) Alleviates Intergenerational Effects of Paternal Neonatal Exposure to Anesthesia With Sevoflurane.
Xu N, Lei L, Lin Y, Ju LS, Morey TE, Gravenstein N, Yang J, Martynyuk AE. Xu N, et al. Anesth Analg. 2020 Oct;131(4):1291-1299. doi: 10.1213/ANE.0000000000005097. Anesth Analg. 2020. PMID: 32925350 Free PMC article.
BACKGROUND: Neonatal exposure to sevoflurane induces neurobehavioral and neuroendocrine abnormalities in exposed male rats (generation F0) and neurobehavioral, but not neuroendocrine, abnormalities in their male, but not female, offspring (generation F1). ...CONCLUS …
BACKGROUND: Neonatal exposure to sevoflurane induces neurobehavioral and neuroendocrine abnormalities in exposed male rats (generatio …
Ablation of Potassium-Chloride Cotransporter Type 3 (Kcc3) in Mouse Causes Multiple Cardiovascular Defects and Isosmotic Polyuria.
Garneau AP, Marcoux AA, Noël M, Frenette-Cotton R, Drolet MC, Couet J, Larivière R, Isenring P. Garneau AP, et al. PLoS One. 2016 May 11;11(5):e0154398. doi: 10.1371/journal.pone.0154398. eCollection 2016. PLoS One. 2016. PMID: 27166674 Free PMC article.
Aortas were also assessed for reactivity to pharmacological agents while isolated from the influence of sympathetic ganglia. This approach led to the identification of unforeseen abnormalities such as lower pulse pressure, heart rate, aortic reactivity and aortic wall thic …
Aortas were also assessed for reactivity to pharmacological agents while isolated from the influence of sympathetic ganglia. This approach l …